ACTIVE IMMUNITY TO POLIOMYELITIS IN CHIMPANZEES FOLLOWING SUBCLINICAL INFECTION
نویسندگان
چکیده
منابع مشابه
Active Immunity to Poliomyelitis in Chimpanzees following Subclinical Infection
This report is concerned with the production of subclinical poliomyelitis in the chimpanzee, and immunity to such infection. Subclinical infection was produced in eight chimpanzees by the administration of virus orally or intracutaneously, and was measured by the production of a virus carrier state and the development of neutralizing antibodies. Immunity was tested by attempting to induce the c...
متن کاملPoliomyelitis in Chimpanzees
The response of eighteen chimpanzees to poliomyelitis virus administered orally and cutaneously has been studied. There were no signs of weakness or paralysis in any of the animals. Sixteen of the eighteen (89 per cent) became infected as measured by intestinal carriage of virus. Only one of twelve was reinfected when challenged with an homologous (or homotypic) strain by the same routes, but s...
متن کاملPassive Immunity to Poliomyelitis in the Chimpanzee
A series of 6 chimpanzees was inoculated orally with stool from a poliomyelitis patient. Three of these animals had been given 170 cc. of homologous, hyperimmune monkey serum prior to inoculation, while three were unprotected. All 6 of the animals were subsequently shown to have poliomyelitis virus in their stools and characteristic lesions in their central nervous systems although none of them...
متن کاملEvidence of Active Immunity to Experimental Poliomyelitis Obtained by the Intranasal Route in Macacus Rhesus
The experiments reported above indicate that the intranasal instillations of pituitrin S and adrephine, alter susceptibility in the rhesus monkey. One-half to two-thirds of the treated animals resisted intranasal infection, and, moreover, most of the resistant animals which had received combined treatment and virus developed active immunity, as indicated by the presence of neutralizing substanc...
متن کاملActive Immunization against Poliomyelitis
1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis. If there is an excess of serum, the degree of immunity is considerably reduced.
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1947
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.85.3.287